Though it was expected for some time, it appears GameInformer has confirmed the title in their upcoming July issue. Apparently, not much is known about the title, except for a couple details:
Cole has a different look in the title
The game takes place in a different city
There will be new powers available for Cole
Cole’s voice (previously played by Jason Cottle) will be replaced by David Sullivan
This means it’s a pretty done deal we will be seeing Sucker Punch revealing InFamous 2 more formally at this year’s E3.
Source: GameInformer via IGN